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This absolutely opens the door to thepossibility of even earlier treatment of neurological diseases bydirect gene transfer and has implications for Parkinson's diseaseALS and even cognitive diseases such as dementia when caused bygene defects." The Powell Gene Therapy Center provided expertise to the Taiwanesephysicians on treating the patients and engineering the correctivegene that spurs production of the absent AADC enzyme. UF's Centerof Excellence for Regenerative Health Biotechnology manufacturedthe vector packaging genetic material it received from Taiwan intovirus particles that were purified characterized and tested forsterility and stability before being shipped to the clinic for usein patients. "We are ecstatic that we manufactured a product that providedtherapeutic benefit to these patients" said Snyder anassociate professor in UF's department of molecular genetics andmicrobiology.
MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Parkinsons disease refers to a group of conditions called movement disorders. In this disease the nervous system gets affected and special neurons that deliver dopamine throughout the body are scrambled gradually. As a result Parkinsons sufferers have tremendously destroyed speech and motor function. Many people look for natural remedies for Parkinsons that can help alleviate the symptoms of this disease.
Kathleen M. Shannon neurologist in theMovement Disorders and Parkinson's Center at Rush and amultidisciplinary team of scientists at Rush. The team analyzedsamples of tissue obtained during colonscopy examinations that tookplace 2-5 years before the first symptom of Parkinson's diseaseappeared in 3 research subjects and all 3 showed thecharacteristic protein in the wall of the lower intestine.
MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Parkinsons disease refers to a group of conditions called movement disorders. In this disease the nervous system gets affected and special neurons that deliver dopamine throughout the body are scrambled gradually. As a result Parkinsons sufferers have tremendously destroyed speech and motor function. Many people look for natural remedies for Parkinsons that can help alleviate the symptoms of this disease.
We have identified a set of new genes that are highly expressed inthe nervous system and have a specific function in a biologicalprocess that is crucial for the activity and viability of thenervous system" explains Eduardo Soriano head of the Neurobiologyand Cell Regeneration group at IRB Barcelona and full professor atthe University of Barcelona (UB). By means of comparative genomic analyses the scientists havediscovered that these genes are found only in more evolved mammalsthe so-called Eutharia these characterized by internalfertilization and development. "This finding indicates therelevance of mitochondrial biology. When the brain evolved in sizefunction and structure the mitochondrial transport process alsobecame more complex and probably required additional regulatorymechanisms" says Soriano.
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